|
KMID : 0617320020110010232
|
|
Journal of Pharmacetical Sceiences Ewha Womans University
2002 Volume.11 No. 1 p.232 ~ p.235
|
|
|
Controlled Release and Stabilization of Cefaclor from Alginate-based Matrices for Oral Delivery Design
|
|
Bak, So-Im
Lee, Jue-Yeon/Song, Hye-Won/Hwang, Jeong-Hyo/Lee, Seung-Jin
|
|
|
Abstract
|
|
|
|
Alginate based polymeric matrices were designed for controlled release and stabilization of cefaclor in gas-trointestinal fluid. Cefaaclor is known to be acid stable and subjected to be degraded at neutral and alkaline pHs. In orderto achieve an effective release profi1e of cefaclor in gastrointestinal tract, a particular strategy in dosage form design shouldbe required from the view point of maintaining its activity. The amphiphilic nature of cefacler allowed its controlled releaseusing ionic polymers based on ionic interaction between the drug and polymers. The thrust of this study was to develop atechnique that delivers cefaclor keeping effrctive release rate in the intestinal tract. Considering the fast degradation of cefa-clor in the intestinal fluid, the matrices were designed to release surplus amount of cefaclor. The alginate baged mntricesdemonstrated increase in release rate in the simulated intestinal fluid, which was favorable to compensate the degraded por-tion of ceflclor. In addition, stabiliration of cefaclor in the intestinal fluid was obtained by employing citric acid that pro-vides an local acidic environment. The matrices might be valuably used for the development of an oral cefaclor dosage form.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|